Reparative action

The recurrent problem of abdominal surgery remains a problem of postoperative adhesions of the abdominal cavity (SPBP) and its related complications.

Currently, many authors point to the high prophylactic efficacy of reparative action (solkoseril, Actovegin, Curiosin, etc.). The aim of our study was to determine experimentally protivospaechnoy efficacy solkoseril.

Male rats Wistar were divided into 3 experimental groups of 6 animals each. After modeling SPBP own way, the animal group 1 (control) series of preventive protivospaechnyh of the abdominal cavity was not introduced, Animal 2-series was introduced 0,25% novocaine solution (2 ml), and animals 3-Series - solkoseril (2 ml). Animals all series derived from the experiment in 14 days by peridozirovki ether anesthesia, blood withdrawal was made on the overall clinical analysis, autopsy study. Severity of adhesions was assessed visually and by using their own automated method of semantic differential (SD). Histological examination was performed by the standard technique with the stain of paraffin sections with hematoxylin-eosin and Van Gieson. Carried out light microscopy, microphotography.

Macroscopically, we found no dependence of the frequency and brand viagra severity of adhesions from an animal belonging to one of the series. Severity of adhesions by diabetes was significantly different between the 1 st series (3,41 ± 0,29) and 2-nd series (1,97 ± 0,25), and between 1 st and 3rd (1,66 ± 0,17) batches (P <0.05). However, no significant difference between the prophylactic efficacy of novocaine and solcoseryl we have not detected (P> 0,05).

Histological examination of the connective tissue adhesions between the parietal and visceral peritoneum leaves the 2-series (procaine) was characterized by thin collagen fibers, many of the stroma and a small number of cell elements. In the third series had more pronounced infiltration of connective tissue cells, more collagen fibers, and as a consequence of a more organized structure of connective tissue.

Thus, we see no feasibility of intraperitoneal application of solcoseryl to prevent postoperative SPBP, but the use of drugs stimulating repair processes to prevent adhesion formation requires further study.

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